Cytarabine can cause serious side effects on your brain or central nervous system that may not be reversible. Cytarabine may also be used for purposes not listed in this medication guide. Last updated on Jul 1, 2020. Available for Android and iOS devices. Women of childbearing potential should be advised to avoid becoming pregnant. Severe and at times fatal CNS, GI and pulmonary toxicity (different from that seen with conventional therapy regimens of Cytarabine) has been reported following some experimental dose schedules of Cytarabine. It is not known whether this drug is excreted in human milk. Voreloxin is in clinical studies, as a single agent and in combination with cytarabine, for the treatment of acute myeloid leukemia (AML). Clinical Oncological Society of Australia, Guidelines and Recommendations for Safe Handling of Antineoplastic Agents. We comply with the HONcode standard for trustworthy health information -. severe drowsiness, confusion, unusual thoughts or behavior; fever, chills, body aches, feeling very ill; stomach pain, bloating, nausea, vomiting, bloody or tarry stools; loss of movement in any part of your body; liver problems--loss of appetite, right-sided upper stomach pain, dark urine, jaundice (yellowing of the skin or eyes); low platelets or red blood cells--pale skin, easy bruising, unusual bleeding, tiredness, feeling light-headed, cold hands and feet; lung problems--pain when you breathe, shortness of breath while lying down, cough with foamy mucus; or. Since Cytarabine is a potent bone marrow suppressant, it should be used cautiously in patients with pre-existing drug-induced bone marrow suppression, impaired liver function. Regulatory Classification. Cytarabine is cytotoxic to a wide variety of proliferating mammalian cells in culture. After receiving an injection, you will be watched closely to make sure you do not have serious side effects. In particular, patients with renal or hepatic function impairment may have a higher likelihood of CNS toxicity after high-dose Cytarabine treatment. Although the mechanism of action is not completely understood, it appears that Cytarabine acts through the inhibition of DNA polymerase. You will need frequent medical tests. These studies showed that when Cytarabine injection was added to Water for Injection, 5% Dextrose in Water or Sodium Chloride Injection, 94 to 96 percent of the Cytarabine was present after 192 hours storage at room temperature. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Five infants were premature or of low birth weight. HOW TO USE: This medication is usually given by injection into a vein by a health care professional. Select one or more newsletters to continue. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. For induction therapy patients should be treated in a facility with laboratory and supportive resources sufficient to monitor drug tolerance and protect and maintain a patient compromised by drug toxicity. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. When large intravenous doses are given too quickly, patients are frequently nauseated and may vomit for several hours post-injection. Cytarabine gains entry into cells by a carrier process, and then must be converted to its active compound, aracytidine triphosphate. Drug type: Cytarabine is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. Chemical stability studies were performed by ultraviolet assay on Cytarabine injection in infusion solutions. This cardiac toxicity may be schedule dependent. Cytarabine is in a class of medications called antimetabolites. Regulatory Classification. Therapeutic abortions were done in five cases. Cytarabine is a known teratogen and should not be used during the first trimester of pregnancy. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Cytarabine drug manufacturers and companies such as Mayne Pharma. Patients treated with high-dose Cytarabine should be observed for neuropathy since dose schedule alterations may be needed to avoid irreversible neurologic disorders. Patients whose drug is withheld until “normal” peripheral blood values are attained may escape from control. The literature should be consulted for the current recommendations for use in acute lymphocytic leukemia. Ten patients treated with experimental intermediate doses of Cytarabine (1 g/m2) with and without other chemotherapeutic agents (meta-AMSA, daunorubicin, etoposide) at various dose regimes developed a diffuse interstitial pneumonitis without clear cause that may have been related to the Cytarabine. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant. Protect from light. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Copyright 1996-2018 Cerner Multum, Inc. Patients can tolerate higher total doses when they receive the drug by rapid intravenous injection as compared with slow infusion. Find patient medical information for Cytarabine Injection on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. INDICATIONS. Cytarabine is usually given together with a … This occurred immediately after the intravenous administration of Cytarabine. for Meitheal Pharmaceuticals There is no antidote for overdosage of Cytarabine. Cytarabine | C9H13N3O5 | CID 6253 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, … Decreased steady-state ... L01BC01 - cytarabine ; Belongs to the class of antimetabolites, pyrimidine analogues. Class of drug. Complete alopecia is more commonly seen with experimental high dose therapy than with standard treatment programs using Cytarabine. Frequent platelet and leucocyte counts and bone marrow examinations are mandatory. Version: 9.01. prednisone, triamcinolone, methotrexate, dexamethasone, Decadron, hydroxyurea, rituximab, Imbruvica, cyclophosphamide, Rituxan. Regardless of initial count, dosage level, or schedule, there is an initial fall starting the first 24 hours with a nadir at days 7 to 9. This study suggests that in patients on Cytarabine being treated with gentamicin for a K. pneumoniae infection, the lack of a prompt therapeutic response may indicate the need for re-evaluation of antibacterial therapy. Chicago, IL 60631 (USA) Cytarabine is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Cytarabine Hospira(Cytarabine): Learn about Cytarabine Hospira's Dosage, Side Effects and indications USES: Cytarabine is used alone or with other medications to treat various types of cancer. Necrotizing leukoencephalopathy occurred in 5 children; these patients had also been treated with intrathecal methotrexate and hydrocortisone, as well as by central nervous system radiation. Therefore, monitoring of plasma digoxin levels may be indicated in patients receiving similar combination chemotherapy regimens. B If experimental high dose therapy is used, do not use a preparation containing benzyl alcohol. (OSHA Work Practice Guidelines), Am J. Health- Syst Pharm, 1996; 53:1669-1685. There are no adequate and well-controlled studies in pregnant women. When necessary the pH is adjusted with hydrochloric acid and/or sodium hydroxide to a pH of 7.4. Cytarabine Injection 100 mg per 5 mL (20 mg per mL), an antineoplastic, is a sterile solution of Cytarabine for intravenous, intrathecal or subcutaneous administration. Tell your doctor at once if you develop signs of infection. One apparently normal infant died at 90 days of gastroenteritis. Cytarabine is employed either as a single agent or in combination with others, specially the anthracyclines, and is the prime example of an antitumor drug specifically acting in the S-phase of the cell cycle because its incorporation into DNA after being activated to the corresponding triphosphate leads to inhibition of strand elongation (Fig. Cytarabine can cause serious side effects on your brain or central nervous system that may not be reversible. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), … Cytarabine is also used to treat leukemia associated with meningitis. To report SUSPECTED ADVERSE REACTIONS, contact Meitheal Pharmaceuticals Inc. at 1-844-824-8426 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. It is characterized by fever, myalgia, bone pain, occasionally chest pain, maculopapular rash, conjunctivitis and malaise. Cytarabine is also used to treat or prevent leukemia associated with meningitis. However, it had no effect on already established delayed hypersensitivity reactions. If the symptoms of the syndrome are deemed treatable, corticosteroids should be contemplated as well as continuation of therapy with Cytarabine. cytarabine is a topic covered in the Davis's Drug Guide.. To view the entire topic, please sign in or purchase a subscription.. Anesthesia Central is an all-in-one web and mobile solution for treating patients before, during, and after surgery. The clinician should monitor the patient's blood uric acid level and be prepared to use such supportive and pharmacologic measures as might be necessary to control this problem. Is cytarabine … It works by slowing or … Cytarabine is often given by continuous intravenous infusion, which follows a biphasic elimination – initial fast clearance rate followed by a slower rate of the analog. Select one or more newsletters to continue. Two patients with childhood acute myelogenous leukemia who received intrathecal and intravenous Cytarabine at conventional doses (in addition to a number of other concomitantly administered drugs) developed delayed progressive ascending paralysis resulting in death in one of the two patients. Less serious toxicity includes nausea, vomiting, diarrhea and abdominal pain, oral ulceration, and hepatic dysfunction. Cytarabine can cause fetal harm when administered to a pregnant woman. Cytarabine Solution for injection drug summary. Cytarabine drug interactions (in more detail). This may be due to potential competitive inhibition of its uptake. Deformities of the head and limbs are most common. Cytarabine can increase your risk of bleeding or infection. When indicated, restart therapy when definite signs of marrow recovery appear (on successive bone marrow studies). Cytarabine has been used effectively alone or with other chemotherapeutic agents in the treatment and maintenance therapy of meningeal leukemia and other meningeal neoplasms (e.g., lymphoma). You should not breastfeed while you are receiving cytarabine. Following 5-day constant infusions or acute injections of 50 mg/m2 to 600 mg/m2, white cell depression follows a biphasic course. This medication is classified as an "antimetabolite." However, in one patient in whom cerebrospinal fluid levels are examined after 2 hours of constant intravenous infusion, levels approached 40 percent of the steady state plasma level. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. In man during administration with little or no accompanying toxicity or third trimester are allergic to it on cytarabine 100. ” peripheral blood values are attained may escape from control How to use: medication. 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